The roles of immune cells and their soluble products during myocardial infarction (MI) are not completely understood. Here, we observed that the percentages of IL-17, but not IL-22, producing cells are reduced in mice splenocytes after developing MI. To correlate this finding with the functional activity of IL-17, we sought to determine its effect on monocytes. In particular, we presumed that this cytokine might affect the chemotaxis of monocytes important for cardiac inflammation and remodeling. We observed that IL-17 tends to reduce the expression of two major chemokine receptors involved in monocyte chemotaxis, namely CCR2 and CXCR4. Further analysis showed that monocytes pretreated with IL-17 have reduced in vitro chemotaxis towards the ligand for CCR2, i.e., MCP-1/CCL2, and the ligand for CXCR4, i.e., SDF-1α/CXCL12. Our results support the possibility that IL-17 may be beneficial in MI, and this could be due to its ability to inhibit the migration of monocytes. © 2012 by the authors; licensee MDPI, Basel, Switzerland.
CITATION STYLE
Troitskaya, M., Baysa, A., Vaage, J., Sand, K. L., Maghazachi, A. A., & Valen, G. (2012). Interleukin-17 (IL-17) expression is reduced during acute myocardial infarction: Role on chemokine receptor expression in monocytes and their in vitro chemotaxis towards chemokines. Toxins, 4(12), 1427–1439. https://doi.org/10.3390/toxins4121427
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