Intracranial internal carotid artery calcifications: Association with vascular risk factors and ischemic cerebrovascular disease

60Citations
Citations of this article
51Readers
Mendeley users who have this article in their library.

Abstract

BACKGROUND AND PURPOSE: Atherosclerotic calcifications are present not only in the extracranial carotid bifurcation but also in the intracranial part of the internal carotid artery. We assessed the association between intracranial internal carotid artery calcifications and cardiovascular risk factors in patients with ischemic cerebrovascular disease and the association between calcifications and the presence of this disease. MATERIALS AND METHODS: Patients undergoing multidetector CT (MDCT) angiography of the carotid arteries for assessment of stenosis degree were included in the study. A semiautomatic custom-made system to quantify calcifications was developed. The associations between the volume of calcifications and cardiovascular risk factors and the type of ischemic cerebrovascular symptoms were assessed with logistic regression. RESULTS: MDCT angiography was performed in 406 patients (age, 62 ± 14 years; 242 men). Men had a significantly higher calcification volume (66 mm 3 ) than women (33 mm 3 ). Calcification volume was positively associated with age in both men and women. Smoking, hypercholesterolemia, and a history of cardiac disease were independently related to the presence of calcifications. A history of cardiac disease and ischemic cerebrovascular disease were independently related to the volume of calcifications. No association was found between calcifications and the presence or type of ischemic cerebrovascular disease in the vascular territory of the intracranial internal carotid artery. CONCLUSIONS: Calcifications were associated with higher age and male gender. The presence and volume of calcifications were independently associated with cardiovascular risk factors. Calcifications were not related to the presence or type of ischemic cerebrovascular disease.

Cite

CITATION STYLE

APA

De Weert, T. T., Cakir, H., Rozie, S., Cretier, S., Meijering, E., Dippel, D. W. J., & Van Der Lugt, A. (2009). Intracranial internal carotid artery calcifications: Association with vascular risk factors and ischemic cerebrovascular disease. American Journal of Neuroradiology, 30(1), 177–184. https://doi.org/10.3174/ajnr.A1301

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free