Abstract
Tumor necrosis factor (alpha) antagonist therapies represent an increased risk of reactivation of tuberculosis. We report two cases of life-threatening disseminated tuberculosis in patients undergoing treatment with infliximab for Crohn's disease including one case of a patient with cerebral tuberculomas.We discuss the implication of tumor necrosis factor (alpha) in the genesis of tuberculosis infection and the features of tuberculosis under infliximab.Tuberculosis screening and eventually preventive chemotherapy should become the standard of care for individual undergoing tumor necrosis factor (alpha) antagonist therapies. (copyright) 2012 .
Author supplied keywords
- BCG vaccine
- Crohn disease
- Mycobacterium tuberculosis
- adult
- article
- azathioprine
- blurred vision
- budesonide
- case report
- clinical examination
- computer assisted tomography
- corticosteroid therapy
- coughing
- digestive system fistula
- disease severity
- erythema
- fever
- human
- human tissue
- imurel
- infliximab
- intestine obstruction
- intracranial tuberculoma
- male
- miliary tuberculosis
- monotherapy
- motor dysfunction
- nuclear magnetic resonance imaging
- papule
- prednisolone 3 sulfobenzoate
- priority journal
- remicade
- respiratory failure
- sepsis
- skin biopsy
- solupred
- thorax radiography
- tuberculin test
- tuberculosis
- tuberculostatic agent
- tumor necrosis factor alpha inhibitor
- vomiting
Cite
CITATION STYLE
C., T., S., C., L., M., P., G., V., A., L., G., … P.-J., S. (2012). Life-threatening disseminated tuberculosis as a complication of treatment by infliximab for Crohn’s disease: Report of two cases, including cerebral tuberculomas and miliary tuberculosis. Journal of Crohn’s and Colitis, 6(9), 946–949. Retrieved from http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L52083924
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