Human cancer results from the accumulation of multiple independent genetic alterations. Studies of inherited and sporadic colorectal cancer have demonstrated that in the overwhelming number of cases the primary muta- tion targets a single signal transduction pathway.Astory has rapidly unfolded in which the Wnt signaling pathway plays a central role in the etiology of this cancer. The sequence of discoveries provides a classic example of the synergy between insights gained from genetic stud- ies of model organisms and cancer biology in man.
Bienz, M., & Clevers, H. (2000, October 13). Linking colorectal cancer to Wnt signaling. Cell. Cell Press. https://doi.org/10.1016/S0092-8674(00)00122-7