Lipoperoxidation and protein oxidative damage exhibit different kinetics during septic shock

31Citations
Citations of this article
28Readers
Mendeley users who have this article in their library.

Abstract

Septic shock (SS)-related multiorgan dysfunction has been associated with oxidative damage, but little is known about the temporal damage profile and its relationship to severity. The present work investigated prospectively 21 SS patients. Blood samples were obtained at diagnosis, 24, 72 hours, day 7, and at 3 months. At admission, thiobarbituric acid reactive substances (TBARSs), plasma protein carbonyls, plasma protein methionine sulfoxide (MS), ferric/reducing antioxidant power (FRAP), total red blood cell glutathione (RBCG), uric acid (UA), and bilirrubin levels were increased (P<.05). Total radical - trapping antioxidant potential (TRAP) and vitamin-E were similar to controls, and vitamin-C was decreased (P<.05). During evolution, TBARS and RBCG increased (P<.001), vitamin-E levels remained stable, whereas plasma protein carbonyls and MS, TRAP, vitamin-C, reduced glutathione, and UA levels decreased (P<.006). After 3 months, plasma protein carbonyls and MS persisted elevated. More severe patients exhibited higher TBARS, TRAP, FRAP, vitamin-C, UA, and bilirrubin levels. Our results suggest early and persistent oxidative stress during septic shock and a correlation between increasing levels of lipoperoxidation and sepsis severity. Copyright © 2008 Max Andresen et al.

Cite

CITATION STYLE

APA

Regueira, T., Andresen, M., Bruhn, A., Perez, D., Strobel, P., Dougnac, A., … Leighton, F. (2008). Lipoperoxidation and protein oxidative damage exhibit different kinetics during septic shock. Mediators of Inflammation, 2008. https://doi.org/10.1155/2008/168652

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free