Long-Term Outcomes After Cryoballoon Pulmonary Vein Isolation

  • Vogt J
  • Heintze J
  • Gutleben K
  • et al.
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Abstract

Objectives: The purpose of this study was to investigate long-term outcomes of freedom from atrial fibrillation (AF) after pulmonary vein (PV) isolation using cryoballoon ablation with balloon-size selection based on individual PV diameters. Background: Data are lacking on long-term outcomes from cryoablation and on the most effective balloon size. Methods: This was a prospective observational study involving 605 consecutively enrolled patients with symptomatic paroxysmal AF (n = 579) or persistent AF. Cryoballoon size was based on magnetic resonance imaging and/or conventional angiograms. Patients were followed up every 3 months during the first year after discharge and every 6 months in the second year. After 24 months, follow-up was on an outpatient basis with documented AF episodes recorded. Results: The PV isolation was achieved without touch-up in 91.1% of patients, using the smaller balloon in 26.7%, the larger balloon in 25.6%, and both balloons in 47.7% of patients. Follow-up data for >12 months (median 30 months; interquartile range 18 to 48 months) were available for 451 patients, 278 (61.6%) of whom were free of AF recurrence with no need for repeat procedures after the 3-month blanking period. Rates of freedom from AF after 1, 2, and 3 repeat procedures (using cryoballoon or radiofrequency ablation with similar success rates) were 74.9%, 76.2%, and 76.9%, respectively. Use of the smaller balloons or both balloons produced the highest rates of long-term freedom from AF. Phrenic nerve palsy occurred in 12 patients (2%), resolving within 3 to 9 months. Conclusions: Rates of long-term freedom from AF after cryoballoon ablation are similar to those reported for radiofrequency ablation. A choice between balloons may improve outcomes. ?? 2013 American College of Cardiology Foundation.

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APA

Vogt, J., Heintze, J., Gutleben, K. J., Muntean, B., Horstkotte, D., & Nölker, G. (2012). Long-Term Outcomes After Cryoballoon Pulmonary Vein Isolation. Journal of the American College of Cardiology, 61(16), 1707–1712. https://doi.org/10.1016/j.jacc.2012.09.033

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