Lutein protects RGC-5 cells against hypoxia and oxidative stress

46Citations
Citations of this article
33Readers
Mendeley users who have this article in their library.

Abstract

Retinal ischemia and oxidative stress lead to neuronal death in many ocular pathologies. Recently, we found that lutein, an oxy-carotenoid, protected the inner retina from ischemia/reperfusion injury. However, it is uncertain whether lutein directly protects retinal ganglion cells (RGCs). Here, an in vitro model of hypoxia and oxidative stress was used to further investigate the neuroprotective role of lutein in RGCs. Cobalt chloride (CoCl(2)) and hydrogen peroxide (H(2)O(2)) were added to a transformed RGC cell line, RGC-5, to induce chemical hypoxia and oxidative stress, respectively. Either lutein or vehicle was added to cultured cells. A higher cell count was observed in the lutein-treated cells compared with the vehicle-treated cells. Our data from this in vitro model revealed that lutein might protect RGC-5 cells from damage when exposed to either CoCl(2)-induced chemical hypoxia or H(2)O(2)-induced oxidative stress. These results suggest that lutein may play a role as a neuroprotectant.

Cite

CITATION STYLE

APA

Li, S. Y., & Lo, A. C. Y. (2010). Lutein protects RGC-5 cells against hypoxia and oxidative stress. International Journal of Molecular Sciences, 11(5), 2109–2117. https://doi.org/10.3390/ijms11052109

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free