The m 6 A‑methylase complex and mRNA export

Abstract

During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs. mRNAs also undergo a number of internal modifications, the most common of which is the N 6 ‑methyladenosine (m 6 A) modification. In this review we discuss the recent evidence of coupling between the m 6 A modification, RNA processing and export.