A study by Tsiairis and Aulehla (2016), published in Cell, reveals that randomized mixtures of dissociated presomitic mesoderm (PSM) cells reestablish wave-like propagating patterns of oscillatory gene expression by tuning the oscillation dynamics in response to surrounding cells. Thus, PSM cells self-organize the phase-coupled oscillators.
Shimojo, H., & Kageyama, R. (2016, February 22). Making Waves toward the Shore by Synchronicity. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2016.02.003