Messenger RNA (mRNA) modification provides an additional layer of gene regulation in cells. In this issue of Cancer Cell, Zhang et al. report that ALKBH5, a demethylase of the mRNA modification N6-methyladenosine, regulates proliferation and self-renewal of glioblastoma stem-like cells by modulating pre-mRNA stability and expression of the FOXM1 gene.
Dixit, D., Xie, Q., Rich, J. N., & Zhao, J. C. (2017, April 10). Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis. Cancer Cell. Cell Press. https://doi.org/10.1016/j.ccell.2017.03.010