Methods to design and synthesize antibody-drug conjugates (ADCs)

13Citations
Citations of this article
146Readers
Mendeley users who have this article in their library.

Abstract

Antibody-drug conjugates (ADCs) have become a promising targeted therapy strategy that combines the specificity, favorable pharmacokinetics and biodistributions of antibodies with the destructive potential of highly potent drugs. One of the biggest challenges in the development of ADCs is the application of suitable linkers for conjugating drugs to antibodies. Recently, the design and synthesis of linkers are making great progress. In this review, we present the methods that are currently used to synthesize antibody-drug conjugates by using thiols, amines, alcohols, aldehydes and azides.

Cite

CITATION STYLE

APA

Yao, H., Jiang, F., Lu, A., & Zhang, G. (2016, February 2). Methods to design and synthesize antibody-drug conjugates (ADCs). International Journal of Molecular Sciences. MDPI AG. https://doi.org/10.3390/ijms17020194

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free