The ability of a human cytomegalovirus-encoded homolog of MHC class I molecules to serve as a peptide receptor was investigated. Sequencing of peptide material eluted from the purified viral protein revealed a mixture of endogenous peptides with characteristics similar to those eluted from conventional class 1 molecules, that is, anchor residues, and a predominance of short peptides derived from cytoplasmic proteins. The possible function(s) of this viral MHC homolog are discussed in light of the finding that it binds endogenous peptides. © 1995.
CITATION STYLE
Fahnestock, M. L., Johnson, J. L., Renny Feldman, R. M., Neveu, J. M., Lane, W. S., & J. Bjorkman, P. (1995). The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides. Immunity, 3(5), 583–590. https://doi.org/10.1016/1074-7613(95)90129-9
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