The ability of a human cytomegalovirus-encoded homolog of MHC class I molecules to serve as a peptide receptor was investigated. Sequencing of peptide material eluted from the purified viral protein revealed a mixture of endogenous peptides with characteristics similar to those eluted from conventional class I molecules, that is, anchor residues, and a predominance of short peptides derived from cytoplasmic proteins. The possible function(s) of this viral MHC homolog are discussed in light of the finding that it binds endogenous peptides.
Fahnestock Ml, Johnson Jl, Feldman Rm, Neveu Jm, Lane Ws, & Bjorkman Pj. (1995). The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides. Immunity, 3(5), 583–590.