The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides

  • Fahnestock Ml
  • Johnson Jl
  • Feldman Rm
  • et al.
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Abstract

The ability of a human cytomegalovirus-encoded homolog of MHC class I molecules to serve as a peptide receptor was investigated. Sequencing of peptide material eluted from the purified viral protein revealed a mixture of endogenous peptides with characteristics similar to those eluted from conventional class I molecules, that is, anchor residues, and a predominance of short peptides derived from cytoplasmic proteins. The possible function(s) of this viral MHC homolog are discussed in light of the finding that it binds endogenous peptides.

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Fahnestock Ml, Johnson Jl, Feldman Rm, Neveu Jm, Lane Ws, & Bjorkman Pj. (1995). The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides. Immunity, 3(5), 583–590.

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