In this issue of Cell, Park et al. (2007) describe the nuclear encoded protein MTERF3 as a negative regulator of mitochondrial DNA transcription initiation. This study highlights a mechanism by which mitochondrial DNA transcription (and therefore oxidative phosphorylation) may be regulated in response to alterations in the cell's physiological and metabolic demands. © 2007 Elsevier Inc. All rights reserved.
Taylor, R. W., & Turnbull, D. M. (2007, July 27). Mitochondrial DNA Transcription: Regulating the Power Supply. Cell. https://doi.org/10.1016/j.cell.2007.07.002