Modeling Calcium Wave Based on Anomalous Subdiffusion of Calcium Sparks in Cardiac Myocytes

6Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

Ca 2+ sparks and Ca 2+ waves play important roles in calcium release and calcium propagation during the excitation-contraction (EC) coupling process in cardiac myocytes. Although the classical Fick's law is widely used to model Ca 2+ sparks and Ca 2+ waves in cardiac myocytes, it fails to reasonably explain the full-width at half maximum(FWHM) paradox. However, the anomalous subdiffusion model successfully reproduces Ca 2+ sparks of experimental results. In this paper, in the light of anomalous subdiffusion of Ca 2+ sparks, we develop a mathematical model of calcium wave in cardiac myocytes by using stochastic Ca 2+ release of Ca 2+ release units (CRUs). Our model successfully reproduces calcium waves with physiological parameters. The results reveal how Ca 2+ concentration waves propagate from an initial firing of one CRU at a corner or in the middle of considered region, answer how large in magnitude of an anomalous Ca 2+ spark can induce a Ca 2+ wave. With physiological Ca 2+ currents (2pA) through CRUs, it is shown that an initial firing of four adjacent CRUs can form a Ca 2+ wave. Furthermore, the phenomenon of calcium waves collision is also investigated. © 2013 Chen et al.

Cite

CITATION STYLE

APA

Chen, X., Kang, J., Fu, C., & Tan, W. (2013). Modeling Calcium Wave Based on Anomalous Subdiffusion of Calcium Sparks in Cardiac Myocytes. PLoS ONE, 8(3). https://doi.org/10.1371/journal.pone.0057093

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free