The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12. © 2007 Elsevier Inc. All rights reserved.
Marzi, A., Mitchell, D. A., Chaipan, C., Fisch, T., Doms, R. W., Carrington, M., … Pöhlmann, S. (2007). Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin. Virology, 368(2), 322–330. https://doi.org/10.1016/j.virol.2007.07.004