Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.

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Abstract

A calcium/calmodulin-dependent protein kinase type II (CaM-K) alpha-subunit cDNA has been cloned from rat brain. This enzyme is encoded by a 5.1-kilobase mRNA expressed exclusively in the brain. Hybridization histochemistry reveals that the CaM-K mRNA expression corresponds to the distribution of the immunoreactive alpha-subunit protein, suggesting that the high enzyme levels in specific brain areas reflect regional differences in gene expression. The sequence of CaM-K alpha-subunit cDNA indicates a 478-amino acid (54-kDa) protein with three functional domains. The domain organization suggests a structural model for calcium/calmodulin-dependent and independent states that might subserve short- and long-term responses to transient stimuli.

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Lin, C. R., Kapiloff, M. S., Durgerian, S., Tatemoto, K., Russo, A. F., Hanson, P., … Rosenfeld, M. G. (1987). Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America, 84(16), 5962–5966. https://doi.org/10.1073/pnas.84.16.5962

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