Are MTHFR C677T and MTRR A66G polymorphisms associated with overweight/obesity risk? From a case-control to a meta-analysis of 30,327 subjects

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Abstract

Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings.

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Fan, S. J., Yang, B. Y., Zhi, X. Y., He, M., Wang, D., Wang, Y. X., … Sun, G. F. (2015). Are MTHFR C677T and MTRR A66G polymorphisms associated with overweight/obesity risk? From a case-control to a meta-analysis of 30,327 subjects. International Journal of Molecular Sciences, 16(6), 11849–11863. https://doi.org/10.3390/ijms160611849

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