Variants in the complement cascade genes and the LOC387715/HTRA1, have been widely reported to associate with age-related macular degeneration (AMD), the most common cause of visual impairment in industrialized countries.
Seitsonen, S. P., Onkamo, P., Peng, G., Xiong, M., Tommila, P. V., Ranta, P. H., … Järvelä, I. E. (2008). Multifactor effects and evidence of potential interaction between complement factor HY402H and LOC387715 A69S in age-related macular degeneration. PLoS ONE, 3(12). https://doi.org/10.1371/journal.pone.0003833