Neuroblastoma Metastases: Leveraging the Avian Neural Crest

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Abstract

Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diagnosis. In this issue of Cancer Cell, Delloye-Bourgeois and colleagues demonstrate that neuroblastoma cell lines and patient-derived xenografts engraft and adopt a metastatic program in chick embryos. They identify Sema3C as a candidate switch that regulates metastatic spread. Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diagnosis. In this issue of Cancer Cell, Delloye-Bourgeois and colleagues demonstrate that neuroblastoma cell lines and patient-derived xenografts engraft and adopt a metastatic program in chick embryos. They identify Sema3C as a candidate switch that regulates metastatic spread.

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Zheng, T., Ménard, M., & Weiss, W. A. (2017, October 9). Neuroblastoma Metastases: Leveraging the Avian Neural Crest. Cancer Cell. Cell Press. https://doi.org/10.1016/j.ccell.2017.09.012

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