Non-long terminal repeat (non-LTR) retrotransposons are present in most eukaryotic genomes. In some species, such as humans, these elements are the most abundant genome sequence and continue to replicate to this day, creating a source of endogenous mutations and potential genotoxic stress. This review will provide a general outline of the replicative cycle of non-LTR retrotransposons. Recent findings regarding the host regulation of non-LTR retrotransposons will be summarized. Finally, future directions of interest will be discussed.
Han, J. S. (2010). Non-long terminal repeat (non-LTR) retrotransposons: Mechanisms, recent developments, and unanswered questions. Mobile DNA. https://doi.org/10.1186/1759-8753-1-15