A monoclonal antibody to the human epidermal growth factor (EGF) receptor was conjugated with polylysine and the resulting conjugate was affinity-linked with DNA (gene). This novel gene delivery system utilizes receptor-mediated endocytosis and would be especially suitable for gene therapy for EGF receptor-overproducing squamous cell carcinomas. © 1994.
Chen, J., Gamou, S., Takayanagi, A., & Shimizu, N. (1994). A novel gene delivery system using EGF receptor-mediated endocytosis. FEBS Letters, 338(2), 167–169. https://doi.org/10.1016/0014-5793(94)80357-9