Novel nonsense mutation of BRCA2 gene in a Moroccan man with familial breast cancer

7Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

Background: Breast cancer is the most common cancer in women worldwide. About 5 to 10% of cases are due to an inherited predisposition in two major genes, BRCA1 and BRCA2, transmitted as an autosomal dominant form. Male breast cancer is rare and is mainly due to BRCA2 than BRCA1 germline mutations. Objective: Molecular study of BRCA2 gene in man with familial breast cancer. Methods: PCR and direct sequencing of BRCA2 gene. Results: Identification of novel heterozygous germline mutation c.6428C>A; p.Ser2143Stop of BRCA2 gene.

Cite

CITATION STYLE

APA

Guaoua, S., Ratbi, I., Lyahyai, J., El Alaoui, S. C., Laarabi, F. Z., & Sefiani, A. (2014). Novel nonsense mutation of BRCA2 gene in a Moroccan man with familial breast cancer. African Health Sciences, 14(2), 468–471. https://doi.org/10.4314/ahs.v14i2.25

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free