The NSm proteins of Rift Valley fever virus are dispensable for maturation, replication and infection

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Abstract

Rift Valley fever (RVF) virus belongs to the Bunyaviridae family of segmented negative-strand RNA viruses and causes mosquito-borne disease in sub-Saharan Africa. We report the development of a T7 RNA polymerase-driven plasmid-based genetic system for the virulent Egyptian isolate, ZH501. We have used this system to rescue a virus that has a 387 nucleotide deletion on the genomic M segment that eliminates the coding region for two non-structural proteins known as NSm. This virus, ΔNSm rZH501, is indistinguishable from the parental ZH501 strain with respect to expression of structural proteins and growth in cultured mammalian cells.

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Gerrard, S. R., Bird, B. H., Albariño, C. G., & Nichol, S. T. (2007). The NSm proteins of Rift Valley fever virus are dispensable for maturation, replication and infection. Virology, 359(2), 459–465. https://doi.org/10.1016/j.virol.2006.09.035

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