How exactly large molecules translocate through nuclear pores has been mysterious for a long time. Recent kinetic measurements of transport rates through the pore have led to a novel translocation model that elegantly combines selectivity with very high transport rates.
Rabut, G., & Ellenberg, J. (2001, July 24). Nucleocytoplasmic transport: Diffusion channel or phase transition? Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(01)00340-2