Odorant representations are modulated by intra- but not interglomerular presynaptic inhibition of olfactory sensory neurons

121Citations
Citations of this article
133Readers
Mendeley users who have this article in their library.

Abstract

Input to the central nervous system from olfactory sensory neurons (OSNs) is modulated presynaptically. We investigated the functional organization of this inhibition and its role in odor coding by imaging neurotransmitter release from OSNs in slices and in vivo in mice expressing synaptopHluorin, an optical indicator of vesicle exocytosis. Release from OSNs was strongly suppressed by heterosynaptic, intraglomerular inhibition. In contrast, inhibitory connections between glomeruli mediated only weak lateral inhibition of OSN inputs in slices and did not do so in response to odorant stimulation in vivo. Blocking presynaptic inhibition in vivo increased the amplitude of odorant-evoked input to glomeruli but had little effect on spatial patterns of glomerular input. Thus, intraglomerular inhibition limits the strength of olfactory input to the CNS, whereas interglomerular inhibition plays little or no role. This organization allows for control of input sensitivity while maintaining the spatial maps of glomerular activity thought to encode odorant identity. Copyright ©2005 by Elsevier Inc.

Cite

CITATION STYLE

APA

McGann, J. P., Pírez, N., Gainey, M. A., Muratore, C., Elias, A. S., & Wachowiak, M. (2005). Odorant representations are modulated by intra- but not interglomerular presynaptic inhibition of olfactory sensory neurons. Neuron, 48(6), 1039–1053. https://doi.org/10.1016/j.neuron.2005.10.031

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free