Hemicrania continua is a strictly unilateral, continuous headache, typically mild to moderate in severity, with severe exacerbations commonly accompanied by cranial autonomic features and migrainous symptoms. It is exquisitely responsive to Indomethacin. However, some patients cannot tolerate treatment, often due to gastrointestinal side effects. Therapeutic alternatives are limited and controlled evidence lacking.
Miller, S., Correia, F., Lagrata, S., & Matharu, M. S. (2015). OnabotulinumtoxinA for Hemicrania Continua: open label experience in 9 patients. Journal of Headache and Pain, 16(1). https://doi.org/10.1186/s10194-015-0502-z