A surprising new mechanism that regulates the plasticity of postnatal neurons is reported in this issue by Sugiyama et al. (2008). These authors show in mice that visual experience triggers cell-to-cell transfer of the homeoprotein Otx2 to cortical interneurons, where it promotes maturation of inhibitory neural circuitry and opens the critical period for plasticity in the visual cortex. © 2008 Elsevier Inc. All rights reserved.
Rebsam, A., & Mason, C. A. (2008, August 8). Otx2’s Incredible Journey. Cell. https://doi.org/10.1016/j.cell.2008.07.029