Pathophysiology of Acute Lymphoblastic Leukemia

  • P. M
  • Borjas-Gutierrez C
  • M. G
  • et al.
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The Acute lymphoblastic leukemia (ALL), it produced as a result of a process of malignant transformation of a progenitor lymphocytic cell in the B and T lineages. In ALL, the majority of the cases, the transformation affects the B lineage cells. Leukemia and other cancers share biological characteristics, as clonality. The molecular alterations that are required for the de‐ velopment of a malignant disease is a rare phenomenon when one considers the large number of target cells susceptible to this condition, in other words, a single genetic change rarely be sufficient for developing a malignant tumor. This means that a small percentage of people (1%) who develop malignant hematological disease, probably only 1 cell mutated in a critical gene for the proliferation, differentiation and survival of progenitor cells. There is evidence sup‐ porting a sequential multistep process, of alterations in several oncogenes in tumor suppressor genes or microRNA genes in cancerigen cells.




P., M., Borjas-Gutierrez, C., M., G., E., L., M., A., & R., J. (2013). Pathophysiology of Acute Lymphoblastic Leukemia. In Clinical Epidemiology of Acute Lymphoblastic Leukemia - From the Molecules to the Clinic. InTech.

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