PCN133 Data Linkage for HPV Vaccination, Screening, and Cervical Cancer Outcomes: Is There an Evidence Base for Public Health Decision-Making on Cervical Cancer Prevention Strategies?

Abstract

OBJECTIVES: To assess the availability of linked data on HPV vaccination, screening, and cervical cancer outcomes to guide public health decision-making on cervical cancer prevention strategies. METHODS: MEDLINE and Google Scholar (1/1/ 2006-12/31/2011) were searched using keywords HPV registry, linkage, and cervical cancer to identify countries with national HPV vaccination. Australia, New Zealand, Denmark, Norway, Greenland, Sweden, Iceland, the United Kingdom, Canada, Mexico, and the United States were selected for detailed analysis based on previous review frameworks (Wong et al. 2010; Sander et al. 2012). Information on infrastructure, outcomes collected, surveillance registries and data linkage for these countries through January 15, 2012 was extracted from official health authority websites and government reports. Documents not publicly available or without data on these topics were excluded. RESULTS: Twenty peer-reviewed articles and health authority documents were selected for review. Of the 11 countries evaluated, 64% (7/11) have national HPV vaccination registries collecting vaccination data and comprehensive cancer registries that include cervical cancer outcomes. Four out of the eleven participate in theWHOHPV Laboratory Network that aims to develop an international reference system for HPV assays to monitor performance of HPV vaccines. Five of the 11 countries have linkage of vaccination, cancer screening, and cancer registry records at the national level; however, the other six countries have potential linkages at provincial/territorial levels. None of the 11 countries had data on HPV DNA genotyping linked with other cervical cancer screening and vaccination data. CONCLUSIONS: While fewer than half of the countries assessed had nationally linked data on HPV vaccination, screening, and cervical cancer outcomes, the remaining countries have potential local-level linkages of these data. Establishing data linkages across these sources of information can enable an evidence base to explore the impact of national vaccination strategies and to inform cervical cancer prevention efforts. .