Percutaneous Pulmonary Valve Replacement: 3-Month Evaluation of Self-Expanding Valved Stents

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Purpose: In a recent study our group established an acute animal model of percutaneous pulmonary valve replacement using self-expanding nitinol stents. The present study was performed to evaluate these valved stents over a 3-month period. Description: Bovine jugular xenografts were sutured into nitinol stents. Transfemoral implantation in the pulmonary position using a modified commercially available application device (with a 22-French outer diameter) was evaluated in 9 sheep. Evaluation: Two sheep died shortly after successful valved stent implantation due to internal venous hemorrhage. Another 1 sheep died 2.5 months after the procedure due to vegetations on the neovalve leading to subtotal stenosis. All other animals survived the 3-month study time (n = 6). An orthotopic pulmonary valved stent position was achieved in 4 animals and a supravalvular position in 1. During the deployment procedure, rhythm disturbances occurred in all animals, and mean arterial blood pressure dropped from 83.9 ± 26.0 mm Hg to 68.3 ± 22.3 mm Hg (p = 0.006) (n = 5). The peak-to-peak transvalvular gradient was 5.1 ± 4.0 mm Hg initially (n = 5), and 3.6 ± 1.6 mm Hg at follow-up (n = 5). Three-month angiographic and echocardiographic follow-up confirmed competent neovalves without paravalvular leakages. Conclusions: After 3 months of implantation, percutaneously implanted memory nitinol valved stents demonstrated good function in the sheep. © 2006 The Society of Thoracic Surgeons.




Attmann, T., Quaden, R., Jahnke, T., Muller-Hulsbeck, S., Boening, A., Cremer, J., & Lutter, G. (2006). Percutaneous Pulmonary Valve Replacement: 3-Month Evaluation of Self-Expanding Valved Stents. Annals of Thoracic Surgery, 82(2), 708–713.

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