Periodontal Treatment with Direct Medication Delivery of Hydrogen Peroxide and Oxygen

  • Keller D
  • Buechel M
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Background: Periodontal disease affects 50% to 80% of the world population and is a host immune system inflammatory response associated with a change within the gingival sulcus or periodontal pocket. Conventional treatment and homecare programs are inadequate in controlling the biofilm that causes this disease. Direct medication delivery has been shown to modify the periodontal biofilm, decrease the microbial virulence, which should prove beneficial for the patient. Method: In this case study the nature of the biofilm microenvironment was modified by delivering a 1.7% hydrogen peroxide gel, oxygen and Vibramycin into the patient’s periodontal pockets using a direct medication delivery method (Perio Tray, Perio Protect LLC St. Louis, MO.). The hydrogen peroxide (Perio Gel, Perio Protect St. Louis, MO) has specific poloxamer and antimicrobial medicinal effects as it generates 5.7X oxygen concentration when hydrogen peroxide disassociates into water and oxygen within the medical device. The medicinal benefits of hydrogen peroxide, oxygen and Vibramycin help control the biofilm. Results: The hydrogen peroxide, oxygen and Vibramycin alter the micro-environment of the patient’s periodontal pockets from a more virulent to less virulent population. This decrease in biofilm virulence and a decrease in bacteria numbers is observed clinically as a decrease in bleeding upon probing and pocket probing depth. Conclusion: Delivering and maintaining hydrogen peroxide, oxygen and Vibramycin in a patient’s periodontal pocket, which alters the biofilm constituency, results in significantly reduced host inflammatory response. The decreased inflammation is observed clinically through decreased bleeding upon probing and decreasing the pocket probing depth of the periodontal pocket.




Keller, D. C., & Buechel, M. (2017). Periodontal Treatment with Direct Medication Delivery of Hydrogen Peroxide and Oxygen. Oral Health Case Reports, 03(01).

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