Persistence of HIV-1 transmitted drug resistance mutations

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Abstract

There are few data on the persistence of individual human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) mutations in the absence of selective drug pressure. We studied 313 patients in whom TDR mutations were detected at their first resistance test and who had a subsequent test performed while ART-naive. The rate at which mutations became undetectable was estimated using exponential regression accounting for interval censoring. Most thymidine analogue mutations (TAMs) and T215 revertants (but not T215F/Y) were found to be highly stable, with NNRTI and PI mutations being relatively less persistent. Our estimates are important for informing HIV transmission models.

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Castro, H., Pillay, D., Cane, P., Asboe, D., Cambiano, V., Phillips, A., … Gunson, R. (2013). Persistence of HIV-1 transmitted drug resistance mutations. Journal of Infectious Diseases, 208(9), 1459–1463. https://doi.org/10.1093/infdis/jit345

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