Phosphorylation of measles virus phosphoprotein at S86 and/or S151 downregulates viral transcriptional activity

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Abstract

Measles virus phosphoprotein (P protein) is a cofactor of the viral RNA polymerase (L protein) that associates with the nucleoprotein-RNA complex to support viral transcription and replication. Here, we report a significant inverse correlation between the phosphorylation level of MV-P protein and viral transcriptional activity. Upregulation of P protein phosphorylation resulted in reduction of viral transcription. Additionally, we found that strong phosphorylation at S86 and S151 of P protein, which may be generally prevented by association with nucleoprotein, downregulates the viral transcriptional activity. These findings suggest that P protein is involved in regulation of viral transcription through changes in its phosphorylation status. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Sugai, A., Sato, H., Yoneda, M., & Kai, C. (2012). Phosphorylation of measles virus phosphoprotein at S86 and/or S151 downregulates viral transcriptional activity. FEBS Letters, 586(21), 3900–3907. https://doi.org/10.1016/j.febslet.2012.09.021

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