Polyomavirus infections and its clinical relevance in cancer patients: A Prospective Study

4Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

BK and JC polyomaviruses (PyV) have been demonstrated to be associated with the pathogenesis of various human cancers. We aimed to investigate the impact of BK and JC polyomavirus infections on several clinical parameters in different human cancers. A total of 150 cancer patients were included in the study (51 patients with solid tumors, 48 patients with lymphomas and 51 patients with leukemias). Amplification of PyV DNA was performed using a semi-nested version of Polymerase chain reaction targeting the T genomic region of PyV. The polyomavirus load was determined using real-time PCR assay. The clinical data were collected. Polyomavirus DNA could be detected in 84 (56%) of 150 of all cancerous patients. The solid tumors had the lowest proportion of JCV (6 (11.8%) of 51), whereas had the highest proportion of JCV (200 copies/μl). JCV was more frequent among NHL patients (30%) and absent in HL patients (0%). During follow-up, PyV positivity decreased significantly (p = 0.004) in lymphoma patients (n = 28). Although PyV positivity decreased significantly from 39% to 7% in 28 of 48 lymphoma patients after treatment, it significantly persisted in leukemic patients after treatment (from 22% to 38%). JC was more frequent among leukemic patients with leukopenia. The presence of JC polyomavirus was more frequent among leukemic patients without any significant impact on their overall survival.

Cite

CITATION STYLE

APA

Loutfy, S. A., Moneer, M. M., Salem, S. E., El-Moniem Abada, E. A., El-Moniem Ahmed, E. A., Ibrahim, L. H., & Mohamed, E. C. B. (2017). Polyomavirus infections and its clinical relevance in cancer patients: A Prospective Study. Journal of Infection and Public Health, 10(1), 22–30. https://doi.org/10.1016/j.jiph.2016.01.008

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free