PON-1 Activity and Plasma 8-Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease

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Abstract

The aim of the study was to estimate association of the extent of angiographically proven coronary artery disease (CAD) with plasma 8-isoprostane F2 (8-iso-PGF2 α ) levels as a reliable marker of lipid peroxidation and serum activity of paraoxonase-1, which demonstrates the ability to protect against lipid oxidation. The study included 105 patients with angiographically documented CAD (CAD+) and 45 patients with negative results of coronary angiography (CAD−). Compared to the control group CAD+ patients were characterized by increased 8-iso-PGF2 α levels ( P=0.007 ) and reduced activity of PON-1 towards paraoxon (PONase, P=0.002 ) and phenyl acetate (AREase, P=0.037 ). Univariate correlation analysis indicated that 8-iso-PGF2 α concentrations were positively associated with the severity of CAD as evaluated by the Gensini score ( R=0.41 , P<0.001 ) while PONase activity ( R=−0.26 , P<0.05 ) and AREase activity ( R=−0.23 , P<0.05 ) were inversely correlated with CAD severity. PONase activity and 8-iso-PGF2 α concentration remained independent determinant of atherosclerosis severity in multiple linear regression after adjusting for age, gender, smoking habits, hypertension, type 2 diabetes, statin therapy, and HDL-C and TAG concentration ( β coefficients −0.267; P<0.05 and 0.368; P<0.001 , resp.). The results suggest that PON-1 activity and 8-iso-PGF2 α concentration are associated with the presence and extent of coronary stenosis and may be considered additional markers of coronary artery disease.

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Kuchta, A., Strzelecki, A., Ćwiklińska, A., Totoń, M., Gruchała, M., Zdrojewski, Z., … Jankowski, M. (2015). PON-1 Activity and Plasma 8-Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease. Oxidative Medicine and Cellular Longevity, 2015, 5136937. https://doi.org/10.1155/2016/5136937

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