Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling molecules in human cancer cells and animal models. In this paper, we discuss PPARs functions in the context of different types of gastrointestinal cancer. Copyright © 2012 Valerio Pazienza et al.
Pazienza, V., Vinciguerra, M., & Mazzoccoli, G. (2012). PPARs signaling and cancer in the gastrointestinal system. PPAR Research. https://doi.org/10.1155/2012/560846