Hepatocellular carcinoma (HCC) arises in the context of cirrhosis and chronic hepatitis B virus (HBV) infections, and the diagnosis is often made at advanced stages. Because early-stage diagnosis improves survival, guidelines recommend screening patients at risk for HCC, such as patients with cirrhosis.
Frenette, C. T., Isaacson, A. J., Bargellini, I., Saab, S., & Singal, A. G. (2019). A Practical Guideline for Hepatocellular Carcinoma Screening in Patients at Risk. Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 3(3), 302–310. https://doi.org/10.1016/j.mayocpiqo.2019.04.005