Meyer et al. find that subjects lacking the AIRE gene, critical for self-tolerance in T lymphocytes, show a broad range of autoantibody specificities, which can have extremely high affinities. The data also suggest that some of these autoantibodies can, surprisingly, prevent some types of autoimmunity, particularly type I diabetes.
Davis, M. M. (2016, July 28). In Praise of Descriptive Science: A Breath of Fresh AIRE. Cell. Cell Press. https://doi.org/10.1016/j.cell.2016.07.018