Preoperative systemic therapy in locally advanced breast cancer: A single institution experience

  • E.M. I
  • A.M. A
  • J.M. Z
  • et al.
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Background: Locally advanced breast cancer (LABC) is common in developing countries and it frequently affects younger women. Patients do very poorly when treated by locoregional therapy alone; therefore, preoperative systemic therapy (PST) is commonly used. Materials and Methods: Medical records of 64 Saudi patients with LABC treated with PST in a single institution were retrospectively reviewed. Results: At diagnosis, most patients were young (median age 41 years), and had poor clinicopathological characteristics. Following surgery, complete pathologic response (pCR) in the breast was achieved in 13 patients (20%). Of 62 patients with known nodal status, 22 (34%) had negative axillary nodes. Presence of estrogen receptor (ER) negative tumour was the only dependent variable that predicted pCR in the breast (P = 0.03). At a median follow-up of 42 months, the median progression-free survival (PFS) was 48 months (95% CI, 20-76 months) and the projected 5-year overall survival (OS) was 68%. The recently published scoring system (J Clin Oncol. 2008 Jan 10;26(2):246-52), was the only variable that independently influenced PFS, while ER negative tumours and presence of lymphovascular space invasion were the only factors that adversely affected OS. Conclusions: Despite the use of standard multimodality approach in the management of patients with LABC, prognosis remains guarded.




E.M., I., A.M., A.-G., J.M., Z., S.S., A., T.R., E., E.E., F., … A.H., L. (2009). Preoperative systemic therapy in locally advanced breast cancer: A single institution experience. Ecancermedicalscience. E. M. Ibrahim, Department of Oncology, King Faisal Specialist Hospital and Research Center, PO Box 40047, Jeddah 21499, Saudi Arabia. E-mail: European Institute of Oncology (Italy). Retrieved from

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