Presenilin-1 and memories of the forebrain

Citations of this article
Mendeley users who have this article in their library.


In this issue of Neuron, Feng and colleagues (2001) report that forebrain-specific Presenilin-1 conditional knockout mice show defects in enrichment-induced neurogenesis in the dentate gyrus. This defect in neurogenesis is associated with enhanced fear memory of contextual cues when animals are subjected to enrichment between training and testing. The authors suggest that neurogenesis in the adult dentate gyrus may serve to clear out old memory traces from the hippocampus, thus leaving the hippocampus available for new memory processing.




McGuire, S. E., & Davis, R. L. (2001, December 6). Presenilin-1 and memories of the forebrain. Neuron. Cell Press.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free