Prognostic significance of preoperative prognostic nutritional index in colorectal cancer: results from a retrospective cohort study and a meta-analysis

  • Yang Y
  • Gao P
  • Chen X
  • et al.
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Abstract

// Yuchong Yang 1,* , Peng Gao 1,* , Xiaowan Chen 1 , Yongxi Song 1 , Jinxin Shi 1 , Junhua Zhao 1 , Jingxu Sun 1 , Yingying Xu 2 and Zhenning Wang 1 1 Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang City, PR China 2 Department of Breast Surgery, First Hospital of China Medical University, Shenyang City, PR China * These authors have contributed equally to this work Correspondence to: Zhenning Wang, email: // Keywords : colorectal cancer, meta-analysis, prognostic nutritional index, prognosis, TNM staging Received : April 29, 2016 Accepted : June 07, 2016 Published : June 17, 2016 Abstract The preoperative prognostic nutritional index (PNI) may forecast colorectal cancer (CRC) outcomes, but the evidence is not conclusive. Here, we retrospectively analyzed a cohort of patients from the Department of Surgical Oncology at the First Hospital of China Medical University (CMU-SO). We also conducted a meta-analysis of eleven cohort studies. Bayesian Information Criterion (BIC) was used to determine the optimal PNI cut-off values for classifying prognosis in the patients from the CMU-SO. The result from CMU-SO and meta-analysis both confirmed that low PNI was significantly associated with a poor prognosis and advanced TNM stages. Among the patients from the CMU-SO, the optimal cut-off values were “41-45-58” (PNI < 41, 41 ≤ PNI < 45, 45 ≤ PNI < 58, PNI ≥ 58), which divided patients into 4 stages. The BIC value for TNM staging combined with the PNI was smaller than that of TNM staging alone (–325.76 vs . –310.80). In conclusion, low PNI was predictive of a poor prognosis and was associated with clinicopathological features in patients with CRC, and the 41-45-58 four-stage division may be suitable for determining prognosis. PNI may thus provide an additional index for use along with the current TNM staging system to determine more accurate CRC prognoses.

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Yang, Y., Gao, P., Chen, X., Song, Y., Shi, J., Zhao, J., … Wang, Z. (2016). Prognostic significance of preoperative prognostic nutritional index in colorectal cancer: results from a retrospective cohort study and a meta-analysis. Oncotarget, 7(36). https://doi.org/10.18632/oncotarget.10148

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