Prospective Cohort Study of Breastfeeding and the Risk of Childhood Asthma

Abstract

Objectives: To study whether the duration of breastfeeding and time for introduction of complementary foods was associated with the risk of childhood asthma. Study design: We used data from the Norwegian Mother and Child Study, a nationwide prospective cohort study that recruited pregnant women from across Norway between 1999 and 2008. Children with complete data of breastfeeding up to 18 months and current age >7 years were eligible (n = 41 020). Asthma as the primary outcome was defined based on ≥2 dispensed asthma medications at age 7 years registered in the Norwegian Prescription Database. We used log-binomial regression models to obtain crude relative risks (RRs) in the main analysis, and adjusted for selected confounders in multivariable analyses. Results: For duration of any breastfeeding, 5.9% of infants breastfed <6 months (adjusted RR [aRR] 1.05, 0.93-1.19) and 4.6% breastfed 6-11 months (aRR 0.96, 0.87-1.07) had dispensed asthma medications at age 7 years compared with 4.6% of infants breastfed ≥12 months (P trend .62). Infants still breastfed at 6 months, but introduced to complementary foods <4 months and 4-6 months, had an aRR of 1.15 (0.98-1.36) and 1.09 (0.94-1.27) respectively, compared with infants fully breastfed for 6 months (P trend .09). Ages at introduction of solids or formula separately were not significant predictors (P trend .16 and.08, respectively). Conclusions: We found no association between duration of breastfeeding or age of introduction to complementary foods and asthma at age 7 years.