Protein translocation as a tool: The current rapamycin story

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Abstract

In cell biology and pharmacology, small chemicals are mostly used as agonists and antagonists against receptors and enzymes. The immunosuppressant rapamycin can serve an entirely different purpose: if employed sensibly, it might function as an inducer of dimerization that is able to rapidly activate enzyme activity inside the intact cell. A number of very recent developments such as photoactivatable derivatives make rapamycin an even more attractive tool for basic science. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Putyrski, M., & Schultz, C. (2012, July 16). Protein translocation as a tool: The current rapamycin story. FEBS Letters. https://doi.org/10.1016/j.febslet.2012.04.061

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