Proton translocation by the respiratory haem-copper oxidases

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Cytochrome c oxidase is a molecular machine that transduces respiratory energy into an electrochemical proton gradient across the mitochondrial or bacterial membrane. Reduction of O2 to water takes place at a binuclear haem-copper site, to which four electrons are transferred from cytochrome c on the outer side of the membrane, and four protons from the inside. An additional and equal contribution to Δμ(H+) generation comes from so- called proton pumping, where four H+ ions are translocated, across the membrane per O2 reduced. Some recent progress in research on the mechanism of energy transduction by this class of enzymes is reviewed.




Wikström, M. (1998). Proton translocation by the respiratory haem-copper oxidases. In Biochimica et Biophysica Acta - Bioenergetics (Vol. 1365, pp. 185–192).

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