Radial quantitative ultrasound and dual energy X-ray absorptiometry: Intermethod agreement for bone status assessment in children

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Abstract

<p> <italic>Aim</italic> . To validate a radial quantitative ultrasound (QUS) system with dual energy X-ray absorptiometry (DXA), a criterion technique in bone status assessment among children. <italic>Methods</italic> . Bone health was evaluated using a radial QUS system (Sunlight Omnisense 8000P) to measure the speed of sound (SOS) at one-third distal radius of the nondominant hand and DXA (Hologic QDR) was used to assess whole body bone mineral density (BMD). <italic>Results</italic> . Some 29.9% of the children were grossly misclassified according to quartiles of BMD and radial SOS. Poor agreement was observed between <italic>Z</italic> -scores of radial SOS and whole-body BMD (mean difference = 0.6 ± 0.9; 95% limits of agreement = −1.4 to 2.6). With a cut-off value of −1.0, radial SOS yielded satisfactory sensitivity (80%) and specificity (93%) for the detection of children with low BMD. <italic>Conclusion</italic> . The observed poor agreement in the present study suggests that radial QUS and DXA are not comparable and hence are not interchangeable in evaluating bone status of the children. </p>

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Chong, K. H., Poh, B. K., Jamil, N. A., Kamaruddin, N. A., & Deurenberg, P. (2015). Radial quantitative ultrasound and dual energy X-ray absorptiometry: Intermethod agreement for bone status assessment in children. BioMed Research International, 2015. https://doi.org/10.1155/2015/232876

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