Rapid Infant Weight Gain and Advanced Skeletal Maturation in Childhood

14Citations
Citations of this article
33Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Objective: To test the hypothesis that rapid infant weight gain is associated with advanced skeletal maturity in children from the United States and South Africa. Study design: Longitudinal data from 467 appropriate-for-gestational-age infants in the Fels Longitudinal Growth Study (Dayton, Ohio) and 196 appropriate-for-gestational-age infants in the Birth to Twenty birth cohort study (Johannesburg, South Africa) were used. Multiple linear regression models tested the association between internal SD score change in weight from 0 to 2 years and relative skeletal age at 9 years, adjusting for body mass index, stature, and other covariates. Results: In both studies, faster infant weight gain was associated with more advanced skeletal maturity (approximately 0.2 years or 2.4 months per SD score) at age 9 years (P <.0001-.005), even when adjusting for the positive associations of both birth weight and body mass index at age 9 years. This effect appeared to be accounted for by the greater childhood stature of subjects with more rapid infant weight gain. Conclusions: Relatively rapid infant weight-gain is associated with advanced skeletal development in late childhood, perhaps via effects on stature. © 2009 Mosby, Inc. All rights reserved.

Cite

CITATION STYLE

APA

Demerath, E. W., Jones, L. L., Hawley, N. L., Norris, S. A., Pettifor, J. M., Duren, D., … Cameron, N. (2009). Rapid Infant Weight Gain and Advanced Skeletal Maturation in Childhood. Journal of Pediatrics, 155(3), 355–361. https://doi.org/10.1016/j.jpeds.2009.03.016

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free