The inflammasome is a macromolecular complex responsible for the proteolytic processing and activation of the secreted cytokine IL-1β. It is assembled and activated in response to upstream intracellular sensors of microbial components and cell injury. Now, Faustin et al. describe an in vitro cell-free reconstitution of the inflammasome, opening up a new avenue to better understand this innate immune pathway of microbe sensing. © 2007 Elsevier Inc. All rights reserved.
Duncan, J. A., & Pan-Yun Ting, J. (2007, March 15). Rebuilding Host-Pathogen Interaction from the Ground Up: In Vitro Reconstitution of the Inflammasome. Cell Host and Microbe. https://doi.org/10.1016/j.chom.2007.02.007