Receptor editing in a transgenic mouse model: Site, efficiency, and role in B cell tolerance and antibody diversification

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Abstract

Mice carrying transgenic rearranged V region genes in their IgH and IgK loci to encode an autoreactive specificity direct the emerging autoreactive progenitors into a pre-B cell compartment, in which their receptors are edited by secondary VK-Jκ rearrangements and RS recombination. Editing is an efficient process, because the mutant mice generate normal numbers of B cells. In a similar nonautoreactive transgenic strain, neither a pre-B cell compartment nor receptor editing was seen. Thus, the pre-B cell compartment may have evolved to edit the receptors of autoreactive cells and later been generally exploited for efficient antibody diversification through the invention of the pre-B cell receptor, mimicking an autoreactive antibody to direct the bulk of the progenitors into that compartment.

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Pelanda, R., Schwers, S., Sonoda, E., Torres, R. M., Nemazee, D., & Rajewsky, K. (1997). Receptor editing in a transgenic mouse model: Site, efficiency, and role in B cell tolerance and antibody diversification. Immunity, 7(6), 765–775. https://doi.org/10.1016/S1074-7613(00)80395-7

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