Receptor oligomerization: From early evidence to current understanding in class B GPCRs

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Abstract

Dimerization or oligomerization of G protein-coupled receptors (GPCRs) are known to modulate receptor functions in terms of ontogeny, ligand-oriented regulation, pharmacological diversity, signal transduction, and internalization. Class B GPCRs are receptors to a family of hormones including secretin, growth hormone-releasing hormone, vasoactive intestinal polypeptide and parathyroid hormone, among others. The functional implications of receptor dimerization have extensively been studied in class A GPCRs, while less is known regarding its function in class B GPCRs. This article reviews receptor oligomerization in terms of the early evidence and current understanding particularly of class B GPCRs.

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Ng, S. Y. L., Lee, L. T. O., & Chow, B. K. C. (2013). Receptor oligomerization: From early evidence to current understanding in class B GPCRs. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2012.00175

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