Reduced serpinB9-mediated caspase-1 inhibition can contribute to autoinflammatory disease

  • van der Burgh R
  • Meeldijk J
  • Jongeneel L
  • et al.
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Abstract

Patients who suffer from autoinflammatory disease (AID) exhibit seemingly uncontrolled release of interleukin (IL)-1β. The presence of this inflammatory cytokine triggers immune activation in absence of pathogens and foreign material. The mechanisms that contribute to 'sterile inflammation' episodes in AID patients are not fully understood, although for some AIDs underlying genetic causes have been identified. We show that the serine protease inhibitor B9 (serpinB9) regulates IL-1β release in human monocytes. SerpinB9 function is more commonly known for its role in control of granzyme B. SerpinB9 however also serves to restrain IL-1β maturation through caspase-1 inhibition. We here describe an autoinflammatory disease-associated serpinB9 (c.985G > T, A329S) variant, which we discovered in a patient with unknown AID. Using patient cells and serpinB9 overexpressing monocytic cells, we show the A329S variant of serpinB9 exhibits unobstructed granzyme B inhibition, but compromised caspase-1 inhibition. SerpinB9 gene variants might contribute to AID development.

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APA

van der Burgh, R., Meeldijk, J., Jongeneel, L., Frenkel, J., Bovenschen, N., van Gijn, M., & Boes, M. (2016). Reduced serpinB9-mediated caspase-1 inhibition can contribute to autoinflammatory disease. Oncotarget, 7(15). https://doi.org/10.18632/oncotarget.8086

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